Jasper Dingemanse Selected Research

almorexant

5/2014	Pharmacokinetic interactions between the orexin receptor antagonist almorexant and the CYP3A4 inhibitors ketoconazole and diltiazem.
4/2014	Assessment of the abuse liability of a dual orexin receptor antagonist: a crossover study of almorexant and zolpidem in recreational drug users.
1/2014	Formulation development for the orexin receptor antagonist almorexant: assessment in two clinical studies.
6/2013	Tolerability, pharmacokinetics, and pharmacodynamics of single-dose almorexant, an orexin receptor antagonist, in healthy elderly subjects.
6/2013	Absence of pharmacokinetic and pharmacodynamic interactions between almorexant and warfarin in healthy subjects.
1/2012	Absolute oral bioavailability of almorexant, a dual orexin receptor antagonist, in healthy human subjects.
1/2011	Pharmacokinetics and tolerability of almorexant in Japanese and Caucasian healthy male subjects.

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Jasper Dingemanse Research Topics

Disease

37	Pulmonary Arterial Hypertension 02/2018 - 04/2003
16	Sleep Initiation and Maintenance Disorders (Insomnia) 01/2022 - 06/2013
10	Hypertension (High Blood Pressure) 01/2021 - 01/2013
10	Headache (Headaches) 12/2020 - 04/2002
9	Body Weight (Weight, Body) 11/2021 - 04/2003
7	Sleepiness 10/2021 - 02/2007
6	Vomiting 01/2021 - 07/2002
6	Nausea 01/2020 - 07/2002
5	Multiple Sclerosis 12/2021 - 05/2015
4	Myocardial Infarction 01/2022 - 01/2020
4	Sleep Wake Disorders 10/2021 - 04/2014
4	Fibrosis (Cirrhosis) 10/2021 - 01/2008
4	Autoimmune Diseases (Autoimmune Disease) 01/2017 - 02/2015
3	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2021 - 01/2020
3	Edema (Dropsy) 01/2021 - 03/2014
3	Fatigue 12/2020 - 01/2012
3	Fabry Disease (Fabry's Disease) 10/2020 - 11/2017
3	Psoriasis (Pustulosis Palmaris et Plantaris) 02/2018 - 02/2015
3	Diarrhea 06/2017 - 08/2009
3	Allergic Rhinitis 01/2015 - 12/2013
3	Asthma (Bronchial Asthma) 01/2015 - 12/2013
3	Type 2 Diabetes Mellitus (MODY) 10/2013 - 10/2009
3	Cystic Fibrosis (Mucoviscidosis) 01/2013 - 02/2012
3	Heart Failure 08/2004 - 04/2002
2	Obstructive Sleep Apnea 01/2022 - 11/2021
2	Liver Cirrhosis (Hepatic Cirrhosis) 10/2021 - 04/2009
2	Breast Neoplasms (Breast Cancer) 11/2020 - 11/2020
2	Anxiety Disorders (Anxiety Disorder) 01/2020 - 01/2003
2	Hemorrhage 01/2020 - 01/2019
2	Hypotension (Low Blood Pressure) 01/2020 - 01/2008
2	Diabetic Nephropathies (Diabetic Nephropathy) 05/2010 - 09/2006
2	Pulmonary Hypertension 02/2005 - 05/2004
1	Apnea 01/2022
1	Acute Lung Injury 12/2021
1	Weight Gain 01/2021
1	Chronic Obstructive Pulmonary Disease (COPD) 01/2021
1	Conjunctivitis 01/2021
1	Dizziness (Lightheadedness) 12/2020
1	Infections 10/2020

Drug/Important Bio-Agent (IBA)

28	Endothelin Receptor AntagonistsIBA 01/2021 - 04/2002
19	Orexin Receptor AntagonistsIBA 01/2022 - 01/2011
18	Bosentan (Tracleer)FDA Link 04/2017 - 04/2002
16	daridorexantIBA 01/2022 - 01/2019
14	macitentanIBA 01/2018 - 03/2012
9	Pharmaceutical PreparationsIBA 01/2021 - 01/2004
8	Sphingosine-1-Phosphate ReceptorsIBA 01/2020 - 12/2013
8	ponesimodIBA 02/2018 - 12/2013
7	aprocitentanIBA 01/2021 - 01/2019
7	selexipagIBA 02/2018 - 01/2014
7	almorexantIBA 05/2014 - 01/2011
6	Epoprostenol (Prostacyclin)FDA LinkGeneric 06/2017 - 04/2003
5	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 01/2021 - 12/2013
5	Endothelins (Endothelin)IBA 01/2019 - 08/2004
5	Epoprostenol ReceptorsIBA 02/2018 - 01/2014
5	miglustat (Zavesca)FDA Link 01/2013 - 08/2009
5	tezosentanIBA 05/2012 - 04/2002
4	Purinergic P2Y Receptor AntagonistsIBA 01/2022 - 01/2020
4	selatogrelIBA 01/2022 - 01/2020
4	clazosentanIBA 01/2021 - 01/2019
4	GlycosphingolipidsIBA 10/2020 - 05/2012
4	EnzymesIBA 10/2020 - 01/2010
3	cenerimodIBA 01/2021 - 01/2020
3	migalastatIBA 10/2020 - 11/2017
3	ceramide glucosyltransferaseIBA 10/2020 - 11/2017
3	OrexinsIBA 01/2020 - 02/2007
3	Endothelin A ReceptorIBA 01/2020 - 01/2019
3	ProstaglandinsIBA 02/2018 - 01/2015
3	2- (2- (1- naphthoyl)- 8- fluoro- 3,4- dihydro- 1H- pyrido(4,3- b)indol- 5(2H)- yl)acetic acidIBA 01/2017 - 12/2013
3	Glucose (Dextrose)FDA LinkGeneric 10/2013 - 10/2009
3	Insulin (Novolin)FDA Link 10/2013 - 10/2009
2	CreatinineIBA 11/2021 - 01/2008
2	Proteins (Proteins, Gene)FDA Link 11/2020 - 11/2020
2	Warfarin (Coumadin)FDA LinkGeneric 05/2016 - 05/2002
2	ambrisentan FDA Link 03/2015 - 03/2014
2	Formyl Peptide Receptors (Formyl Peptide Receptor)IBA 12/2014 - 12/2013
2	MK-1597IBA 12/2013 - 10/2013
2	Endothelin Receptors (Endothelin Receptor)IBA 08/2013 - 01/2008
2	1- (2- (4- benzyl- 4- hydroxypiperidin- 1- yl)ethyl)- 3- (2- methylquinolin- 4- yl)ureaIBA 05/2010 - 10/2009
2	AlbuminsIBA 05/2010 - 09/2006
2	Sildenafil Citrate (Viagra)FDA Link 11/2009 - 01/2008
2	urotensin IIIBA 10/2009 - 09/2006
2	Type 5 Cyclic Nucleotide PhosphodiesterasesIBA 05/2008 - 01/2008
2	Endothelin-1 (Endothelin 1)IBA 01/2008 - 05/2004
2	Transaminases (Aminotransferases)IBA 01/2004 - 04/2002
1	ACT-1004-1239IBA 12/2021
1	Citalopram FDA LinkGeneric 10/2021
1	SodiumIBA 01/2021
1	Ethanol (Ethyl Alcohol)IBA 12/2020
1	Rosuvastatin Calcium (Crestor)FDA Link 11/2020
1	lemborexantIBA 11/2020
1	seltorexantIBA 11/2020
1	suvorexantIBA 11/2020
1	GalactosidasesIBA 10/2020
1	Midazolam (Versed)FDA LinkGeneric 04/2020
1	eculizumab FDA Link 01/2020
1	ACT-709478IBA 01/2020
1	ACT-539313IBA 01/2020
1	Prasugrel Hydrochloride FDA Link 01/2020

Therapy/Procedure

7	Therapeutics 10/2020 - 09/2006
1	Self Administration (Administration, Self) 01/2021